Dominion cards are classified into several types, which determine how they can be used during gameplay and how they interact with other cards. A card's types are listed on the bottom of the card.
The majority of cards have only one type, but some cards have two or even three; two cards have four (Dame Josephine and Werewolf). If a card has multiple types, it has membership in all of them for all purposes. For instance, Harem is a Treasure–Victory card; cards that have a special interaction with Treasure cards, such as Mine, and cards that have a special interaction with Victory cards, such as Crossroads, will both respond to Harem. One card, Courtier, has abilities that are sensitive to how many types another card possesses.
A card is not a member of types that are not listed on the bottom of the card, even if they have abilities that resemble those of cards of that type. For instance, Masquerade can be used to put undesirable cards into an opponent's deck, or to trash desirable cards from it, but it is not an Attack card because it does not have "Attack" listed at the bottom of the card.
Many card types are associated with a specific color; on cards of a given type, the background frame surrounding the card art and text are tinted in the appropriate color. Cards with certain combinations of types have two colors.
 The types
 Basic types
Cards of these four types occur in all or almost all games of Dominion, and can appear as the only type on a card.
- Action. Action cards may be played during the Action phase of a player's turn. A player may play only one Action card unless some effect provides them with "+ Actions". Action cards may have a variety of different effects when played. The majority of Kingdom cards are Actions, but not all, so it is possible to play a game of Dominion with no Action cards (The probability of this happening by chance is on the order of 10–10). Action cards have white frames unless they are also Reactions, Durations, Ruins, or Reserves. Most Action card Kingdom piles contain 10 cards, Rats and Port contain 20 and 12 cards, respectively. Action-Victory card piles contain 8 or 12 cards.
- Treasure. Treasure cards may be played during the Buy phase of a player's turn; at the start of this phase, any number of Treasure cards may be played in any order. A few Action cards also allow Treasures to be played during a player's Action phase. Most Treasure cards provide some amount of ; some have other effects when played in addition (or instead). All games of Dominion include the basic Treasure cards Copper, Silver, and Gold. Other basic Treasures are added under certain circumstances, and some Kingdom cards are Treasures as well. Treasure cards have yellow frames. Most Treasure card Kingdom piles contain 10 cards. Treasure-Victory card piles contain 8 or 12 cards.
- Victory. Victory cards are usually worth at the end of the game to a player who has them in their deck. All games of Dominion include the basic Victory cards Estate, Duchy, and Province. The additional basic Victory card Colony may be included in games using Kingdom cards from Prosperity, and some Kingdom cards are Victory cards as well. Victory cards have green frames. All Victory card piles contain 8 cards in a 2-player game and 12 in a 3- or 4-player game.
- Curse. Curses are worth –1 at the end of the game, and are the only card type to consist of only one card name. All games of Dominion include Curses in the supply, though in many games Curses will never be gained or otherwise interacted with. They have purple frames. The number of Curses in a game is equal to ten times the number of players after the first - 10 Curses for a 2-player game, 20 for a 3-player game, and so forth.
 Multi-expansion special types
Cards of these types appear in multiple Dominion expansions, but never appear as the only type on a card.
- Attack. The "Attack" type has no special rules of its own, but several cards refer to the type and interact with Attack cards—for instance several cards have special effects that are triggered when an Attack card is played. Attack cards usually inflict harmful effects on the opponents of the player who plays them, though not all cards that have the potential to harm opponents have the Attack type. Attack cards appear in all expansions, and this type is not associated with a color.
- Duration. Duration cards have effects that often last beyond the turn they are played; they are not discarded from play until the Cleanup phase of the last turn on which they do something. Duration cards were introduced in Seaside, and make appearances in later expansions starting with Adventures.
- Reaction. Reaction cards have optional effects that are triggered by specified events (e.g., an Attack card being played or a card being gained) when the card is somewhere not visible to players other than its owner (usually its owner's hand). When a Reaction card is triggered, on any turn including the owner's own turn, the owner may reveal it and carry out whatever abilities it has. Reaction cards appear in most expansions, and have blue frames.
 Single-expansion special types
Cards of these types typically occur in only one Dominion expansion.
- Prize. Prize cards sit outside the supply and may be gained only as an effect of playing Tournament. Prizes appear in Cornucopia and are not associated with a color.
- Shelter. Shelter cards may replace Estates in players' starting decks in games using Kingdom cards from Dark Ages. There are three differently-named Shelters; each player starts with one of each. Shelters do not appear in the supply and may not be gained from anywhere; the only ones in the game are the ones players start with. Shelters appear in Dark Ages and have red frames.
- Ruins. Ruins are cards with very weak (but not harmful) effects that are included in the supply in games using Looters. There are five differently-named Ruins, but a single supply pile which is shuffled, so players do not know which Ruins are in the supply in what proportions or in what order. All Ruins are Action cards. Ruins appear in Dark Ages and have brown frames.
- Looter. Looter cards have effects that can cause Ruins to be gained; in a game in which one or more Looters are present (in the Supply or via a Black Market deck), Ruins are included in the supply. All Looters are Action cards. Looters appear in Dark Ages and are not associated with a color.
- Knight. Knights are a single Kingdom card pile consisting of ten differently-named cards with similar but distinct effects. The Knights pile in the supply is shuffled, so players do not know in what order the Knights will be available to be gained. All Knights are Action–Attack cards. Knights appear in Dark Ages and are not associated with a color.
- Reserve. Reserve cards are set aside on a Tavern mat when played, and can usually be called back into play to have an additional effect at a later time. Reserves appear in Adventures, and have tan frames.
- Traveller. Travellers, when discarded from play, can be exchanged for stronger cards. Travellers appear in Adventures and are not associated with a color, but are marked with a large arrow behind the card text.
- Gathering. Gathering cards collect tokens on their Supply piles, which can be taken after a certain condition is met. Gatherings appear in Empires and are not associated with a color.
- Castle. Castles are a Split pile with eight differently-named cards with similar but different effects. All Castles are Victory cards. Castles appear in Empires and are not associated with a color.
- Night. Night cards are played during your Night phase, after your Buy phase. Nights appear in Nocturne, and have black frames and white text.
- Heirloom. Heirlooms replace your starting Coppers, when certain kingdom cards are in the game. They appear in Nocturne and are not associated with a color.
- Fate. Fate cards have abilities that cause Boons to be received. They appear in Nocturne and are not associated with a color.
- Doom. Doom cards have abilities that cause Hexes to be received. They appear in Nocturne and are not associated with a color.
- Spirit. Spirit cards are non-Supply cards that can be gained by Exorcist and a few other cards. They appear in Nocturne and are not associated with a color.
- Zombie. Zombie cards are cards that start in the trash that are used when playing with Necromancer. They appear in Nocturne and are not associated with a color.
 Non-card types
These types are not "cards" in a gameplay sense, but are printed on cards.
- Events, introduced in Adventures, mark effects that players can pay for. They are in the landscape orientation, and have silver frames.
- Landmarks, from Empires, mark effects that give players additional means to score (or lose) . They are in the landscape orientation, and have dark green frames.
- Boons, from Nocturne, mark special effects that can be activated by Fate cards. They are in the landscape orientation, and have golden frames.
- Hexes, from Nocturne, mark special effects that can be activated by Doom cards. They are in the landscape orientation, and have dark purple frames.
- States, from Nocturne, mark status effects that apply to one player. They are in the landscape orientation, and have rusted frames.
In early drafts of Dominion, there was a type called "Token", which included Curse and Confusion. When Confusion was cut from the game, the type was renamed after its only remaining member, Curse.
To date, the only type other than the main four that has appeared as the only type on a card is Night.