The second edition of Dominion was an update to all pre-Empires sets that started in Fall 2016. It involved a number of formatting changes, such as a bigger font where possible, better wordings, and the replacing of all masculine pronouns ("he", "his") with gender-neutral pronouns ("they", "their"). It was most pronounced in the Base and Intrigue sets, which saw a number of functional changes to existing cards, as well as the removal and replacement of some cards that, in retrospect, seemed weak or not fun to play with.
Currently, all sets have been released under the second edition except for Alchemy. Proofs of second edition promotional cards have been made, but not all have been released yet. All cards, except for some from Guilds, have been updated on Dominion Online.
For consistency, this wiki will use second edition rules and wordings wherever possible.
 Formatting changes
The formatting changes were first announced a few days before Empires was previewed:
In addition to these, previous sets received some wording changes, such as Cellar's, shown to the right. For the most part, these wording changes have no effect on how the card is played; however, a few received functional changes:
- Moneylender, Throne Room, Mine received a "you may" wording for accountability purposes
- Masquerade was changed so players with no cards in hand are skipped
- Embargo was changed so each Curse gained per token on a pile is a separate event, rather than gaining all of them at once
- Outpost was changed to function in a similar way to Mission
- Possession was changed so the Possessing player also receives all tokens gained
- Trade Route was changed to trash before gaining , which matters if trashing a card that can gain Victory cards when trashed
- Scheme was changed so you can no longer choose Actions that are not discarded that turn, such as Durations
A few cards did not receive functional changes, but instead had their wording changed to match their intended function, where previously it was ambiguous:
- Nomad Camp was changed to make it clear it doesn't visit, as previously its wording matched Villa's, which does visit
- Coin of the Realm, Royal Carriage now refer to finishing "playing" an Action, as opposed to "resolving", which had never been referenced on any other card
- Black Market now explicitly says the player may play Treasures before buying a Black Market card
- Envoy now says "put in hand" rather than "draw", matching its intended function to ignore the -1 Card token
- Stash lets you look at what remains of your deck when you shuffle, in order to retain its function despite the new rule (see below)
With the re-release of Guilds & Cornucopia (as one set), a major visual change was made: all references to "take a Coin token" were changed to "+X Coffers". This has no effect on any actual gameplay, but does let the text on the relevant cards take up a little less space, and highlights the taking of Coffers by making it a vanilla bonus.
 Rule changes
With the release of the second editions for the base set and Intrigue, their rulebooks were also updated. For the most part, this was simply streamlining the rules and putting them together in a more compact, friendly way, but there was one, somewhat subtle change to the rules with regards to shuffling. Previously, when you wanted to draw a card (or otherwise do something with your deck), and your deck was empty, you shuffled, then continued drawing. So if you played Smithy with 2 cards left in your deck, you would have drawn those 2, then shuffled, and drawn 1 more. In the second edition, when your deck is running low, you first check to see if there's enough left to do something with, and if there's not, you shuffle your discard pile, and put that under what's left of your deck. So in the previous situation, with 2 cards left in your deck when you play Smithy, you'd shuffle your discard pile, slide it under those 2 cards, and then draw your 3 cards. Donald X. has cited the ruling as making it easier for situations other than drawing with a near-empty deck.
 Removed cards
See: Removed cards
 Added cards
To replace the cards removed from the base set and Intrigue, 7 new cards were added to each set. Some functioned as fairly direct replacements (such as Patrol for Scout), but others filled needs that Donald X. had felt were lacking in the sets. For instance, the first edition of the base set had several big money enablers, but not a lot of engine support, leading some players of the base game to view it as a solved game where you mostly bought Treasures, so the second edition added several cantrips to balance the set strategically.